2007 Jun 15; 462(2):266-72. J Surg Res. Gut. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. Yale J Biol Med. 1998 Aug 10; 1366(1-2):177-96. 1999 03; 276(3):G591-8. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Gastroenterol Hepatol (N Y). Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Fibrogenesis Tissue Repair. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. 2002 Sep; 123(3):877-8. PLoS One. J Hepatol. Hepatology. Nature. Alteration of interferon-a/ receptors in chronic hepatitis B patients. J Clin Invest. Neurogastroenterol Motil. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. 2002 Oct; 4(5):769-81. Nat Rev Gastroenterol Hepatol. Am J Respir Cell Mol Biol. 2021; 12(3):891-920. 2017 12; 1(10):1043-1057. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. Tacke F, Trautwein C, Yagmur E, Hellerbrand C, Wiest R. Matrix metalloproteinase gene delivery for liver fibrosis. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. 1985 Apr; 5(4):684-91. Role of NADPH oxidases in liver fibrosis. 2004 Nov; 40(5):1106-15. 2020 May 05; 56(5). Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice. The gut-liver axis and the intersection with the microbiome. Transient induction of c-jun during hepatic regeneration. NEK1 mutations in familial amyotrophic lateral sclerosis. Am J Epidemiol. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 2007 Nov; 2(4):243-4. Carcinogenesis. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Gastroenterology. 1989 Feb 16; 337(6208):661-3. Hepatology. Circulation. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective 2014 Dec; 60(6):1920-8. Amyotroph Lateral Scler Frontotemporal Degener. Exp Biol Med (Maywood). Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Clin Gastroenterol Hepatol. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. 1991; 10(3-4):452-5. Medicina (Kaunas). Proc Am Thorac Soc. Derived automatically from this person's publications. See more options in the Advanced Search tab. Hepatology. What is the potential role of antifibrotic agents for the treatment of liver disease? Gastroenterology. Note that an individual publication can be assigned to more than one field. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. 2011 May; 53(5):1433-5. This graph shows the total number of publications by year. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 2013 Feb 01; 12(3):381-2. Next-generation academic medicine. 1994 Sep; 3(9):1695-7. J Immunol. Hepatology. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. 2014 Aug; 124(8):3566-78. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. 1999 Aug; 14(8):1272-80. J Clin Immunol. Gastroenterology. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Circulation. 1987 Dec 25; 262(36):17690-5. Nature. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. 2007 Jun; 22 Suppl 1:S73-8. Mol Cell Biol. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. J Gastroenterol Hepatol. J Gastroenterol Hepatol. Clin Gastroenterol Hepatol. 2005 Apr 08; 280(14):13374-82. 2011 Jun; 31(3):521-32. 2021 01; 335:113496. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Liver: DNA methylation controls liver fibrogenesis. 2020 12; 72(6):2182-2196. 2002 Dec; 36(6):1498-508. Signal transduction during liver regeneration. Luedde T, Rodriguez ME, Tacke F, Xiong Y. 2019 03 29; 10(1):1406. Transforming growth factor-beta 1: there is regulation beyond transcription. 2003 Jul; 39(1):38-46. 2011 May; 53(5):1730-41. Proc Natl Acad Sci U S A. 2003 Apr 15; 170(8):4053-60. J Biol Chem. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. Mechanisms of liver fibrosis and its role in liver cancer. Cell Cycle. Front Mol Biosci. J Clin Invest. Nat Rev Gastroenterol Hepatol. Modulation of constitutive collagen gene expression by lipid peroxidation. Cell Mol Gastroenterol Hepatol. JCI Insight. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Am J Hum Genet. Science. 1992 Jul-Aug; 11(6):443-52. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 1999 Jan 06; 1453(1):161-74. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Hepatol Commun. Aliment Pharmacol Ther. 2009 Jan 16; 378(3):348-53. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. 1989 Aug 11; 17(15):6055-64. Clin Gastroenterol Hepatol. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Cancer Res. 2004 Feb; 126(2):529-40. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). 2021; 8:790032. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. 2000; 35 Suppl 12:80-3. Aliment Pharmacol Ther. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Hepatology. 2005 Feb; 115(2):209-18. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. Hepatology. Am J Physiol Cell Physiol. 2020 11 03; 32(5):878-888.e6. To see the data as text. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Current and prospective therapies for hepatic fibrosis. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. 2021 05; 134:105933. 2010; 2010:362847. J Immunol. 2008 Nov; 135(5):1729-38. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. Carethers will report directly to the chancellor and is part of the leadership team. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Double-strand gap repair results in homologous recombination in mouse L cells. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Yang L, Magness ST, Bataller R, Rippe RA. Exercise training attenuates age-associated diastolic dysfunction in rats. 2013 Apr; 20(4):649-58. 2001 Jul; 34(1):89-100. 2007 Aug; 22(8):1256-64. 2015 Nov-Dec; 49 Suppl 1:S69-73. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. J Cardiovasc Med (Hagerstown). 2009 Jan; 49(1):6-8. The role of Smad3 in mediating mouse hepatic stellate cell activation. 2021 11; 25(11):2149-2159. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Hepatol Res. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Hepatology. 2007 Feb; 27(1):28-43. 2013 Dec; 58(6):1930-40. 2006 Aug; 116(8):2058-9. PLoS One. Am J Pathol. 2007 Apr-Jun; 6(2):83-8. Le TA, Chen J, Changchien C, Peterson MR. 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